고감도 맞춤형 항암제 동반진단 분석 장비

INTEKMEDI   →  고감도 맞춤형 항암제 동반진단 분석 장비

고감도 맞춤형 항암제 동반진단 분석 장비

Real-time Confocal FLIM (iRT-FLIM-001)

실시간 공초점 형광수명 이미징 기술은 항암제 등 약물진단 분석,
실시간 암 병변 검사, 유기 전자소자의 실시간 검사 기술로써 활용가치가 높은 첨단 분광 검사 기술입니다.

Realtime Fluorescence Lifetime Imaging Microscope

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Confocal microscope body

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Data Acquisition Board

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High-speed Digitizer

Confocal microscope body

Data Acquisition Board

High-speed Digitizer

Features

  • Fit-free Real-time FLIM
    • Imaging speed: 0.5 fps with 308×256 pixels
    • Detecting photon count:
      >100MHz with 10MHz laser pulse rate (10 photons per 1 laser pulse)
  • Automated Whole Slide Imaging
    • <15 mins for 1cm x 1cm sample
  • Simultaneous Dual mode FLIM analysis
    • Analog-Mean-Delay and Phasor Analysis
  • Automated Fluorescence Lifetime Calibration

Applications

  • Bio-applications
    • Whole Slide Imaging Analysis / Spatial biology (FISH, IF)
    • Cancer Diagnosis (Microenvironment analysis, e.g. pH, oxidation status)
    • Metabolic Imaging (e.g. NAD(P)H, FAD autofluorescence imaging)
    • fÖrster Resonance Energy Transfer (FRET) Analysis
  • Material Science
    • Characterization of fluorescent materials
      (quantum dots, organic dye, organic light-emitting diode(OLED))

Specifications

Laser module
Laser lines Optical fiber coupled Nanosecond Pulsed Laser
– 4 colors : 405, 488, 520, 635 nm
*Compatible with an external fiber-coupled laser
Scanner module
Scanner Two independent galvanometer mirrors
Scan resolution 308 x 256 or 512 x 512 pixels
Scan speed 1 ~ 1000Hz variable line frequency ; 0.5 fps at 308 x 256 pixels
Pinhole Motorized switching pinhole (0.5 – 10 Airy size)
Detector module
Detection range 230 – 870 nm
Detector Single PMT with filter wheel (Four channels) with sequential switching detection
Emission filter Motorized switching filter wheel or single exchangeable emission filters
Microscope module
Body Dedicated inverted microscope body
*Compatible with Commercial microscope body; Nikon, Olympus, Zeiss,
Leica microscope with side-port
XYstage Motorized stage, Stroke 115 mm x 75 mm
Interchangeable specimen holders for glass slides, well plates, petri-dishes
Z-drive Motorized stage – 15 mm travel range / 250 nm step size min.
Objective lens Olympus objective lens (20x / 60x)
Nosepiece Motorized nosepiece (6 positions) and controller (Jog dial)
Accessories Stage jog dial
Digital Cameras – Bright Field Imaging
Electronic module
Data Processing Module High-Speed Digitizer – 2 channel analogy input (AC Coupling), 1 GSPS/Channel Data acquisition board
Ultimate PC GPU for high computing power (NVIDIA TITAN RTX)
Controller Dedicated electronics ; control of laser, scan module, detector module
Power consumption : 100~240V, 450VA, 50/60Hz
PC Dedicated computer and monitor with signal processing boards
OS : Windows 10, 64bit
Power comsumption : 100~240V, 700VA, 50/60Hz

Gallery

  • Bovine Pulmonary Artery Endothelial (BPAE) Cells
    • 20x Objective (20 FOVs) – Total Acquisition time: 3 min
  • Mouse Kdney Section
    • 20x Objective (420 FOVs) – Total Acquisition time: 45 min